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The researchers further validated these findings using the Nrf2 inhibitor brusatol and the HO-1 inhibitor Znpp, which subsequently reduced cell viability, increased the levels of apoptotic factors such as Bax and caspase-3, and decreased the levels of mitochondrial biogenesis-related proteins such as PGC1-

References 1 ParikhKAntanaviciuteAFawkner-CorbettDJagielowiczMAulicinoALagerholmCet al