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They are well employed to treat type 2 diabetes and obesity due to effectively stimulating insulin response to food intake, preventing the release of glucagon, slowing gastric emptying, and causing feelings of satiety

GLP-1 Agonists and SGLT-2 Inhibitors: Summary of Cardiovascular Outcomes in Patients Who Have Diabetes Mellitus With and Without Established CVD A 2021 BMJ clinical practice guideline provided recommendations for the use of SGLT-2 inhibitors and GLP-1 agonists based on a network meta-analysis of 764 randomized trials with more than 400,000 participants