The GLP-1R agonists appear a promising more efficacious pharmacological treatment option for obesity given the success of liraglutide and semaglutide, and hopefully in the future clinical trials will investigate the ability of the other relevant agonists to induce weight loss in obese individuals with/without diabetes
Image acquisition Scans were conducted at the Sir Peter Mansfield Imaging Centre, University of Nottingham, using a 7 Tesla Philips Achieva scanner (Philips Medical Systems, Best, The Netherlands), a volume transmit head coil, and a 32-channel receive head coil
So, the current protocol is that patients need to check in with their provider for weekly injections so that there is no accidental misuse of the drug
Additionally, improvements in fibrosis may not directly translate to immediate clinical benefits, complicating the assessment of treatment efficacy