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Activated microglia release reactive oxygen and nitrogen species, pro-inflammatory cytokines, and other neurotoxic mediators that exacerbate oxidative stress and mitochondrial damage
Astragaloside IV protects heart from ischemia and reperfusion injury via energy regulation mechanisms
Its synthesis also requires methylation, making creatine an important link between SAM demand and mitochondrial energy
The general healing process can be divided into three overlapping phases: (1) inflammatory phase (days 15), (2) repair/proliferative phase (days 514) and (3) remodelling phase (days 1490+) (Hope and Saxby 2007)
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