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Z68.30 BMI 30.0-30.9, adult Z68.31 BMI 31.0-31.9, adult Z68.32 BMI 32.0-32.9, adult Z68.33 BMI 33.0-33.9, adult Z68.34 BMI 34.0-34.9, adult Z68.35 BMI 35.0-35.9, adult Z68.36 BMI 36.0-36.9, adult Z68.37 BMI 37.0-37.9, adult Z68.38 BMI 38.0-38.9, adult Z68.39 BMI 39.0-39.9, adult Z68.41 BMI 40.0-44.9, adult Z68.42 BMI 45.0-49.9, adult Z68.43 BMI 50.0-59.9, adult Z68.44 BMI 60.0-69.9, adult Z68.45 BMI 70 or greater, adult Note: For pediatric patients aged 2-19 years, BMI percentiles are used: Z68.51 BMI less than 5th percentile for age Z68.52 BMI 5th percentile to less than 85th percentile for age Z68.53 BMI 85th percentile to less than 95th percentile for age Z68.54 BMI greater than or equal to 95th percentile for age 3

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The potential clinical implications of these observations have been confirmed by a recent multicenter trial involving over 4000 patients, in which dulaglutide resulted in approximately a 14% reduction in the risk of cognitive decline after 5 years of therapy [22]

In animal models of neonatal hypoxicischemic encephalopathy, the same positive results were obtained (84, 85)