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NAD+ works through sirtuin-mediated deacetylation of NF-kB subunits

neuroimaging features (1) The most common finding is T2/FLAIR hyperintensity with strongly restricted diffusion affecting gyri in the parieto-occipital and temporal regions.(31589567) (2) Basal ganglia can be involved, which may be a poor prognostic sign.(31589567) (3) Characteristically, there is sparing of the thalami, white matter, and cerebellum