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It is also known as periorbital hyperpigmentation (POH)

Specifically, melatonin can upregulate the expression of superoxide dismutase (MnSOD), glutathione peroxidase (GSH-Px) and catalase (CAT) to prevent cell stress and injury ( 3.2 Melatonin and mitochondrial dynamics In addition to mitochondrial biogenesis, melatonin inhibits fission and promotes fusion to affect mitochondrial dynamics, which contributes to the damaged mitochondria elimination and mitochondrial energy supply recovery (Figure 3)

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14ln) did not show consistent alterations