This suggests a potential shift from testosterone replacement in males with obesity and low testosterone, instead treating excess weight and metabolic health, which can restore hormone levels and preserve fertility
Finally, medications that can affect your period include: Hormonal birth control, which can cause breakthrough bleeding Copper intrauterine devices (IUD), which are nonhormonal but can cause heavy periods during the first year you use them Blood thinners and aspirin, which can cause heavier bleeding What Symptoms to Track If youre noticing period changes on semaglutide, tirzepatide, or other GLP-1s, it can be helpful to create a symptom tracking checklist
[15] [27] In October 2025, the FDA further expanded the indication for semaglutide (as Rybelsus) to reduce the risk of major adverse cardiovascular events (cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke) in adults with type 2 diabetes who are at high risk for these events
Patients may report that food simply tastes less appealing or that they experience diminished pleasure from eating