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The cyclodextrins comprising hydrophilic substitutions adopt what may be described as cone-liked shapes having a hydrophobic inner cavity and a hydrophilic outer surface formed by the many hydrophilic substitutions capable of forming hydrogen bonds with neighbouring water molecules, thereby improving water solubility [T

El diagnstico diferencial incluye enfermedad de Addison, sndrome de Peutz-Jeghers, lengua negra vellosa, mcula melantica y nevus melanoctico1

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