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Physiology, fetal circulation, in StatPearls [Internet]

(144) demonstrated that CIH adversely affected the function and cellular ultrastructure of the hypothalamicpituitary-gonadal (HPG) axis in male rats, evidenced by nuclear deformation and consolidation, vacuole formation within the cellular matrix, and mild mitochondrial swelling, which collectively resulted in diminished levels of FSH, LH, and testosterone

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Current clinical studies on DOR primarily focus on genome sequencing and mutation identification, while the underlying disease mechanisms and signaling pathways remain underexplored