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V.et al (2017)

Pharmacokinetics of platinum accumulation The in vivo pharmacokinetic characteristics of platinum-based agents may determine their tissue accumulation levels, anti-tumor efficacy, and related toxicity

We rated the certainty for each comparison and outcome as high, moderate, low, or very low, taking into consideration the risk of bias [26], inconsistency [27], imprecision [28, 29], indirectness [30], and publication bias [31]

Signs you may be taking too little: Slow recovery from exercise or illness, persistent fatigue despite other support, high inflammatory or oxidative markers on labs, skin looking dull or aging faster than expected, chemical/fragrance sensitivities (suggests detox pathways are sluggish)