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Potential Side Effects While generally considered safe when used appropriately, potential side effects can include: Injection site reactions (redness, itching, irritation) Headaches Nausea Dizziness Water retention (mild) Increased appetite Flushing or tingling sensation More severe side effects are rare and often associated with excessive dosing or prolonged use, similar to those seen with supraphysiological levels of HGH, such as carpal tunnel syndrome, insulin resistance, or acromegaly