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Drug-to-lipid ratios usually fall between 1:5 and 1:20 for effective encapsulation, meaning active ingredients make up 5% to 17% of total lipid mass

35 However, more extensive atrophy of the gastric mucosa (multifocal atrophic gastritis) seems to be associated with an increased risk of progression to gastric neoplastic lesions

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An in vitro study indicated that elevated renal levels of BHB could be detrimental, as it activates the TGF-/Smad3 pathway, resulting in increased collagen fiber production and reduced cell proliferation [102]