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For carriers of the effect allele at rs6265, these habits tend to produce a stronger measurable return because they directly reinforce the signaling environments where this variant has its greatest influence

doi: 10.1186/s13293-016-0060-3 123 SenZDDanyeliLVWoelferMLamersFWagnerGSobanskiTet al

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Indeed, a high proportion of the markers tested in our study localised to where cells differentiate to establish the IRS, and it appears their presence is necessary to prevent damage or to stabilise ROS in cells during the differentiation process