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Together, it is clear that anti-IGF-IR agents may paradoxically stimulate tumor microenvironment remodeling to boost IGF signaling through alternative pathways, leading to cancer resistance to anti-IGF-IR agents

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Rheumatology 57 , 826830 (2018)

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10.3390/ijms25073812

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Additionally, mitochondrial GSH transport allows this pool to be relatively independent from the cytosol, which when depleted does not affect the mitochondrial GSH pool

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