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similarly, while the niacinamide in this compounded B-Complex is in a moderate dose, caution is advised in patients with untreated peptic ulcers or significant hepatic impairment, as even moderate niacin supplementation could aggravate these conditions (e.g

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The synthesis constitutes a formal total synthesis, since the research groups only prepared the known intermediate cobyric acid, whose chemical conversion to vitamin B 12 was previously reported