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Neuropsychopharmacology 48(5):797805

Notably, although there was not a statistically significant increase in biliary disease among GLP-1 receptor agonist users in this study, the FDA 2 added warnings and precautions about acute cholecystitis and biliary disease to the label in late 2022 based on data from placebo-controlled RCTs as well as other observational data 3

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Similarly, untreated type 2 diabetes mellitus is associated with decreased expression of occludin (Chehade et al., 2002) and increased vascular permeability (Sheikh et al., 2022)