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These hybrids exhibited superior neuroprotective effects and lower cytotoxicity compared with curcumin alone, activated ARE, chelated ferrous ions and scavenged ROS, thereby protecting cells from oxidative stress and ferroptosis, ultimately promoting neuronal survival (104,127,128)

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8,2022 The mechanism behind this interesting finding appears to be ethanols competitive utilization of the CYP 2E1 substrate, which diminishes the NAPQI byproduct of phase I APAP metabolism

The residue-specific reactivities and k red values for C151 and C208 in roGFP2(SSG) as well as active-site residue C29 in reduced dithiol PfGrx C88S and monothiol PfGrx C32S/C88S in Fig