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A Ca2+ signaling system stimulated by the insulinotropic hormone glucagon-like peptide-1-(737)

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The state of chromatin is key in regulating gene expression and it is driven by two types of PTMs: (1) acetylation of lysine at the histone tail resulting in the activation of transcription and (2) methylation of lysine at the histone tail resulting in activation or repression of transcription depending on its position on the histone tail ( Despite a lack of knowledge regarding the exact mechanistic relationship between EDCs and epigenetic signatures, proposed mechanisms to date can be divided into two categories: gene-specific action and global action (Kouzmenko et al., 2010

134 (17), e184663