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Consequently, strategies that preserve lean mass during active GLP-1RA therapy and stabilize metabolic regulation during transition or withdrawal are essential components of sustainable obesity care

Quercetin alleviates kidney fibrosis by reducing renal tubular epithelial cell senescence through the SIRT1/PINK1/mitophagy axis

Because GIPR activation is glucose-dependent, this entire cascade engages fully only when blood glucose exceeds approximately 5.6 mmol/L (100 mg/dL), which explains the low hypoglycemia rate observed in SURPASS trials even at the 15 mg dose [6]

In clinical trials, gastrointestinal adverse events were reported by a significant proportion of patients, though most were mild to moderate in severity and transient in nature