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NLRP3 senses a wide array of endogenous and exogenous danger signals, including microbial products, environmental toxins, and host-derived DAMPs, making it a central player in inflammatory responses

Regarding the specific topic of uremic toxins, different studies have demonstrated that uremic toxins, such as indoxyl sulfate [253], acrolein [254], indole-3-acetic acid [255], urea, and p -cresol [256], may directly prompt eryptosis