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The potential anti-fatigue targets of resveratrol (i.e., TP53, PIK3R1, AKT1, PIK3CA, and MAPK1) were identified by network pharmacology, with high binding activity with resveratrol, and the animal experiments showed that resveratrol could prolong the exercise tolerance of mice, reduce the levels of uric acid, blood lactic acid, and blood urea nitrogen, and alter the glycogen storage (Ma et al., 2023)