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Disorders of metabotropic glutamate (mGlu) receptors and neurotrophins have significant negative effects on neuroplasticity, leading to depression, but LAC regulate brain type 2 metabotropic glutamate (mGlu2) receptors and N-methyl-D-aspartic acid (NMDA) receptors to induce antidepressant effect (8385)

Others experience a prolonged adjustment period

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