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The chondrocytes used in this study were isolated from eight donors (15-, 70-, 73-years-old female, and 42-, 69- and 70-years-old male) without the sign of cartilage degradation

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Behavioral intervention consisted of counseling by a dietitian or similarly qualified healthcare professional every 4 weeks via in-person visits or telephone on adherence to a reduced-calorie diet (500 kcal deficit a day relative to the energy expenditure estimated at randomization) and increased physical activity (150 minutes a week encouraged, for example, walking), both recorded daily (via a diary, app or other tools, which were reviewed during counseling sessions)