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Although these data do not entirely negate the argument that metformin mediates its anti-hyperglycemic actions via an inhibitory action on mitochondria complex 1, the evidence strongly suggests that further inhibition of function would worsen, and contribute to, the toxic effects of metformin, such as lactic acidosis, that are, albeit very rare (11)

7 A meta-analysis of outcomes data from completed cardiovascular outcome trials suggests that, apart from saxagliptin, DPP-4 inhibitors have a neutral effect on the risk of cardiovascular death, myocardial infarction, stroke and hospitalisation for heart failure

Now at week 28, I weigh 176 pounds and cannot remember the last time I felt nauseated from my injection

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