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Yet leptinopenic mice ( i.e., those with low levels of leptin) failed to develop a good appetite, though their ghrelin levels rose

Additionally, there are sometimes problems with nutrient absorption. Concern about nutrient deficiencies is driving up demand for protein shakes, multivitamins, mineral supplements and other nutrient-supplying products

You do have these risks, but then you're also eliminating risks, too, and that's the balance that you have to take into account when you're thinking about starting these up and talking with your healthcare provider