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In very rare cases, more serious symptoms like swelling of the face or difficulty breathing can occur

Many of these plant-based compounds also exhibit anti-angiogenic properties and can enhance the efficacy of conventional therapies (66)

Although the development of specific IRE1 activators remains primarily at a preclinical stage, a promising cancer therapeutic approach would be to utilize small molecule IRE1 activators to induce ferroptosis selectively in tumors or to restore ferroptosis in tumors that have developed resistance to this mechanism of cell death

Ether fraction of methanol extracts of Gastrodia elata, medicinal herb protects against neuronal cell damage after transient global ischemia in gerbils