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Enkephalins are the physiological ligands of opioid receptors, and apart from their role in pain perception, they may benefit mood and reduce stress when upregulated [11]

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Table 1 Antihyperglycemic agents for use in type 2 diabetes [116132] Table 2 Maximum daily dose of glucose-lowering medications (regular release formulations unless specified with footnotes) Initiating Pharmacotherapy After counselling and support for health behaviour modification is provided, pharmacotherapy may be required to reach glycemic targets and to optimize cardiorenal risk (Figure 1)