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1 About the SELECT trial and SCORE real-world study SELECT was a randomized, double-blind, parallel-group, placebo-controlled trial designed to evaluate the efficacy of Wegovy (semaglutide) 2.4 mg versus placebo as an adjunct to standard of care for the prevention of MACE in people with overweight or obesity and established CVD with no prior history of diabetes

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In addition, no changes in the structure of the Gcg gene was found, with no evidence for duplication or loss of exons that encode glucagon-like hormone sequences ( Supplementary Table 2 and Supplementary Figure 5 )