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As is the case for within-pathway correlations, there are also significant cross-pathway correlations between respective purine and tryptophan (TRP) pathway metabolites

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5 Conclusion In conclusion, the incidence of DPN varies from nearly 20% to over 70% in patients with DM, which severely hampers quality of life and even leads to amputation

Consequently, the presence of a signal should be interpreted as an indication of potential risk that needs to be further evaluated in the context of robust, well-controlled clinical studies