Generally, the diabetes formulations (Mounjaro, Victoza) receive better coverage than the weight management formulations (Zepbound, Saxenda)
Indeed, an opposite approach, as the pulse feeding strategy, whereby ~ 80% of daily protein is consumed in a single meal, has been shown to improve nitrogen retention in older women and to enhance lean mass preservation in malnourished elderly patients [47]
In a large phase 3 obesity trial (ACHIEVE-1), orforglipron at daily doses of 3, 12 and 36 mg caused approximately: Diarrhoea: 1926% of participants (vs 9% on placebo) Nausea: 1318% (vs 2% on placebo) Constipation: 817% (vs 4% on placebo) Vomiting: 514% (vs 1% on placebo) Across multiple studies, 617% of people stopped treatment because of side effects, mostly gut-related symptoms
You can do all of that and end up with nothing, Raufman said