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Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis

The following themes summarize key areas of ongoing investigation: N NMT, NAD , and Energy Metabolism NNMT catalyzes the methylation of nicotinamide, diverting potential NAD precursors into alternative metabolites

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Pten haploinsufficient mice show broad brain overgrowth but selective impairments in autism-relevant behavioral tests