Hicks et al., 2007
Innovative tools have emerged, like BBB-on-a-chip , providing researchers with deeper insights into the BBB behavior and vulnerabilities
Key insights from the review: Rapid growth of the field since 2019, led by the US, China, and Germany Strong focus on #stroke, #Alzheimers disease, #Parkinsons disease, and bioactive compounds from traditional Chinese medicine Identification of core molecular hubs: STAT3, IL6, TP53, AKT1, and JUN Major mechanistic hotspots include apoptosis, NLRP3 inflammasome, microglial polarization, and NF-B/JAK-STAT/PI3K-AKT pathways Why it matters The analysis highlights a paradigm shift away from one drugone target approaches toward multi-target, systems-level therapeutic strategies, better aligned with the multifactorial nature of neuroinflammatory CNS diseases
Safety and Considerations The allure of peptide therapy lies in its potential health benefits, but safety should always take precedence