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Start your intake Understanding the GLP-1 Receptor and How Semaglutide Works Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist, meaning it binds to specific receptors in your body that regulate appetite, blood sugar, and digestion

A receptor is a protein with a very specific shape that can be thought of as a lock

These mechanisms are linked to slowed proliferation and enhanced apoptosis in preclinical studies

Another study published by Diabetes, Obesity & Metabolism in June 2025 further supported this link, concluding that the five-year risk of developing NAION doubled in patients using GLP-1 drugs compared to non-users