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These compendia use various criteria for the conditions under which a non-FDA approved indication would be included, including a judgment by editorial staff regarding the quality and quantity of evidence, and the magnitude of benefit versus harms

15 , 23 GSH depletion in the brain is a common finding in patients with neurodegenerative conditions eg Alzheimers disease and Parkinsons disease, which can cause neurodegeneration prior to disease onset

second, the importance of IGF-1 monitoring as the central safety parameter in study models