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AT-SIRT3OE mice exhibited improved insulin sensitivity in HFD-fed mice, through alleviating infiltration of macrophage and pro-inflammatory macrophage polarization in the epididymal AT

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injections of 100 nmol kg 1 MK-801 ( n = 10), 100 nmol kg 1 GLP-1 ( n = 10), 100 nmol kg 1 GLP-1MK-801 ( n = 10) or vehicle (isotonic saline, n = 10) for 14 days