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Statistical analysis After analysis of variance (one-way ANOVA), data were tested for statistically significant differences between the groups (before and after 12 and 24 weeks of the treatment) by means of Students t-test for paired and unpaired data, as appropriate

[DOI] [Google Scholar] 13.Khavinson V.K., Egorova V.V., Timofeeva N.M., Malinin V.V., Gordova L.A., Gromova L.V

Studies examining the timing of combined administration have consistently shown that simultaneous or near-simultaneous administration produces maximal synergy, with the synergistic component declining as the interval between administrations increases beyond 15-30 minutes