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This phenomenon is primarily attributed to its strict administration time window, potential risk of side effects, and a wide range of contraindications
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Among the numerous partners that interact with NRF2 regulating its activity, two members of the CNC-bZIP protein family BTB and CNC homolog 1 (BACH1) and BTB and CNC homolog 2 (BACH2) are two negative regulators of NRF2: they compete with NRF2 for the binding to ARE sequences of target genes, thereby preventing the production of antioxidant enzymes and cellular defense against toxicity [232, 233]
Myricitrin attenuates high glucose-induced apoptosis through activating akt-nrf2 signaling in H9c2 cardiomyocytes
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