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Glutathione is critical for the activation of immune system cells and cell regeneration

However, MRP1 is unlikely to adopt the ATP-dependent transition from inward to outward conformation to transport a single molecule of GSH, because if such was the case, a strong stimulated GSH efflux would require the hydrolyzation of a large number of ATP, and this would not comply with the very low ATPase activity of MRP1 57