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Skyrizi Common side effects include: Plaque psoriasis and psoriatic arthritis : upper respiratory infections, headache, fatigue, injection-site reactions, and fungal skin infections Crohn's disease : upper respiratory infections, headache, joint pain, stomach pain, injection-site reactions, anemia, fever, back pain, and urinary tract infections Ulcerative colitis : joint pain, fever, injection-site reactions, and rash The side effects seen in children with plaque psoriasis were generally similar to those reported in adults

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Cellular assays have enabled detailed examination of second messenger dynamics, such as cyclic AMP generation and calcium mobilization, while animal models have provided insight into systemic signal coordination and feedback regulation along the hypothalamic pituitary axis