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Furthermore, the literature indicates that aside from their benefits in weight management and glycemic control, GLP-1 RAs have favorable effects on metabolic profiles, including blood pressure and lipid levels 22

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PKM2 specifically interacts with the STAT3 and HIF1a transcription factors and enhances them, together exerting pro-oncogenic programs in which HIF1a is aberrantly activated despite a normoxic environment (Traxler et al., 2022)