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In May 2004, Congress followed by directing the Under Secretary of Defense Acquisition, Technology and Logistics (USD [AT&L]) to encourage DoD acquisition program managers and prime contractors (holders of direct government contracts) to make significantly more SBIR Phase III contract awards and also to present a comprehensive report by March 31, 2005

It is defined by the presence of antibodies to thyroid peroxidase (TPO), the thyroid enzyme that oxidises iodide to iodine for thyroid hormone synthesis ( Reference Effraimidis and Wiersinga 4 )

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