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Their use has been limited by the presence of adverse effects such as weight gain, water retention (edema, heart failure), bone fractures and a purported association with bladder cancer.24 Consequently, these drugs are usually reserved for use in the third therapeutic step

A comprehensive GLP-1 programcombined with functional nutritionmay support: By integrating functional nutrition, the program also addresses dietary patterns, micronutrient status, gut health, and inflammatory drivers that can directly impact metabolic and hormonal health

Despite that CARTs precise physiological role remains unclear, largely due to the lack of well-defined, specific CART receptors 10 , CART contributes to the regulation of alcohol consumption via the VTA, LH and CeA 11,12

Brain-penetration and neuron-targeting DNA nanoflowers Co-delivering miR-124 and rutin for synergistic therapy of Alzheimer's disease