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However, we mitigated the potential confounding effect of CAD through the use of MR analysis and by rigorously selecting genetic instruments that were strongly associated with GLP-1RAs, while excluding SNPs associated with CAD and other pleiotropic pathways

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Patients with pre-existing tachyarrhythmias , particularly atrial fibrillation or atrial flutter, should be evaluated carefully before initiating GLP-1 therapy