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Act Dermatol 37: 182-183 Rehberger et al (2006) Therapy of skin metastases in malignant melanoma

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carcinogens Nitrogen & Sulfur oxides - respiratory and cardiovascular damage Pharmaceuticals - non-endogenous compounds encountered via contaminated environments Anesthetic gases (Isoflurane) - poorly ventilated medical or hazmat scenes Antibiotic residues in food or water Opioid and fentanyl particulate contamination Hormone disruptors - contaminated water systems Food Additives and Contaminants - intentionally or unintentionally added during food production, storage, or packaging Additives - artificial colors (Red 40), preservatives (BHA, BHT), emulsifiers, flavor enhancers (MSG) Contaminants BPA - plastics, can linings

These results justify the reason why individuals complain that they experience excess histamine dumps, which are sporadic exacerbation of symptoms during sleep leading to itch palpitations and awakenings