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As with all insulin-containing preparations, the glucose lowering effect time course of SOLIQUA 100/33 may vary in different individuals or at different times in the same individual and depends on many conditions, including the area of injection as well as the injection-site blood supply and temperature [see Clinical Pharmacology (12.2)]

The damage inflicted upon the intestinal mucosa facilitates the translocation of lipopolysaccharides from the normal bowel flora and other immune-stimulatory molecules from the intestinal lumen into the bloodstream

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