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International Brazilian Journal of Urology

Total and progressive sperm motility were significantly decreased in the Model group, but Anaerococcus transplantation markedly improved both parameters, similar to high-dose MOS treatment

Rather than pursuing unproven combinations of investigational and licensed agents, patients are encouraged to: Engage with NHS weight management services , which offer multidisciplinary support including dietary advice, behavioural therapy, and pharmacotherapy where appropriate including orlistat and, where eligible, GLP-1-based medicines Discuss licensed options with their GP if they meet eligibility criteria, including referral pathways for bariatric surgery in line with NICE obesity guidance Participate in clinical trials if interested in investigational agents such as retatrutide, through legitimate research pathways listed on the NIHR Clinical Research Network or ClinicalTrials.gov The safest and most effective treatments are those supported by robust clinical evidence, prescribed by qualified clinicians, and obtained through regulated supply chains

For use as approved by the Independent Review Board (IRB) according to the IRB Charter (see www.novonordisk-trials.com)