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However, the precise contribution of each receptor system to overall efficacy and the potential for receptor-specific side effects remain active areas of investigation in ongoing clinical trials

That's a reason to keep on top of your nutrition and strength-training while on these drugs, he writes, "especially for older people like me, who are [already] susceptible to muscle loss." There are people who should steer clear of GLP-1 drugs, Kessler notes, including those with a personal or familial history of certain thyroid and endocrine cancers, those with chronic kidney disease, pancreatitis, inflammatory bowel diseases, uncontrolled diarrhea or constipation or gastroparesis, or if you are pregnant

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Lowering and maintaining visceral fat requires a lifestyle and nutrition change longterm to reset the brain-VAT set point