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After further examination of the included papers, the literature searches yielded a final result of 29 studies considered as relevant for the systematic review and 21 studies suitable for the meta-analyses

Cohort definitions and stratification Patients were divided into two propensity scorematched cohorts: Semaglutide Cohort: Patients receiving semaglutide (RxNorm: 1991302) within one year preceding fertility treatment

Benefits of the Single-Dose Pen One injection per week Convenient administration Reduced treatment burden Simplified dosing Potentially improved adherence Familiar Wegovy injection experience For patients progressing to higher-dose semaglutide therapy, the single-dose device offers a straightforward and convenient treatment option

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