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Once in the nucleus, Nrf2 binds to antioxidant response elements (AREs) and induces the expression of over 500 cytoprotective genes, including superoxide dismutase (SOD) and glutathione peroxidase (GPx) 9,10,11 , thereby enhancing the cells resilience against more significant stressors

Zinc predominantly functions as a cofactor in enzymes, stabilizing protein structures through its interaction with specific amino acid residues, such as cysteine and histidine, thereby contributing to the secondary and tertiary of target proteins [49, 50]

GLP-1 also inhibits the secretion of glucagon

Regarding administration preferences , both medications are typically administered as once-weekly subcutaneous injections